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Title: Thiamin deficiency and uncomplicated falciparum malaria in Laos
Authors: Mayfong Mayxay
Ann M. Taylor
Maniphone Khanthavong
Siamphay Keola
Tiengkham Pongvongsa
Samlane Phompida
Rattanaxay Phetsouvanh
Nicholas J. White
Paul N. Newton
Mahosot Hospital
National University of Laos
Nuffield Department of Clinical Medicine
Centre of Malariology
Phalanxay District Clinic
Savannakhet Provincial Malaria Station
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Mar-2007
Citation: Tropical Medicine and International Health. Vol.12, No.3 (2007), 363-369
Abstract: Objective: Thiamin deficiency complicates severe Plasmodium falciparum malaria in Thailand and may contribute to acidosis. We therefore estimated the frequency of biochemical thiamin deficiency in patients presenting with uncomplicated falciparum malaria in southern Laos. Methods: Red cell transketolase activation coefficients (α) were measured in 310 patients presenting with uncomplicated falciparum malaria and 42 days after starting treatment. Results: Twelve per cent of patients had biochemical evidence of severe deficiency (α values >1.31) at presentation, declining to 3% 42 days later. Conclusion: Thiamin deficiency was common in Lao patients admitted with uncomplicated P. falciparum infection and was reduced following treatment of malaria and multivitamin supplementation. The role of this preventable and treatable disorder in malaria and other acute infections, and the incidence of beriberi in rural Laos, needs further investigation. © 2007 Blackwell Publishing Ltd.
ISSN: 13653156
Appears in Collections:Scopus 2006-2010

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