Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/24647
Title: Reduced intensity stem cell transplantation for treatment of Class 3 Lucarelli severe thalassemia patients
Authors: Suradej Hongeng
Samart Pakakasama
Ampaiwan Chuansumrit
Nongnuch Sirachainan
Thanyachai Sura
Artit Ungkanont
Suporn Chuncharunee
Saengsuree Jootar
Surapol Issaragisil
Mahidol University
Keywords: Medicine
Issue Date: 1-Dec-2007
Citation: American Journal of Hematology. Vol.82, No.12 (2007), 1095-1098
Abstract: Bone marrow transplantation is the only therapeutic option that can potentially eliminate thalassemic disease. Early results indicated that children in Class 3 Lucarelli had a much worse outcome because of high nonrejection mortality and high rejection rate. In the present study, reduced intensity stem cell transplantation (RIT) was performed in eight Class 3 Lucarelli patients conditioned by busulfan, fludarabine, and anti-lymphpcute globulin. One of the eight patients additionally received thiotepa, and total lymphoid irradiation (TLI), while one only received TLI. All patients received hydroxyurea 20 mg/kg/day daily ≥3 months before RIT. Peripheral blood stem cell (PBSCs) were given to a target number of CD34+ cells more than 5 × 10 6 cells/kg of recipient weight. Seven patients received T cell nondepleted PBSCs from matched siblings while one patient received purified CD34+ cells from two HLA antigen mismatched maternal PBSCs. The graft-versus-host disease (GvHD) prophylaxis included cyclosporine or tacrolimus and mycophenolate mofetil. Initially, an engraftment of donor cells was observed in all eight patients, but subsequently only six of eight patients had stable full donor engraftment. There were no deaths or Grade 3-4 acute GvHD in our patients. The present study lends support that the regimens described here produced minimal toxicity and resulted in stable full donor engraftment in the majority of the severe Class 3 Lucarelli thalassemia patients. © 2007 Wiley-Liss, Inc.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36749007160&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/24647
ISSN: 10968652
03618609
Appears in Collections:Scopus 2006-2010

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