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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/24672
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dc.contributor.authorJun Ren Zhuen_US
dc.contributor.authorBrian Tomlinsonen_US
dc.contributor.authorMoo Ro Youngen_US
dc.contributor.authorKui Hian Simen_US
dc.contributor.authorYuan Teh Leeen_US
dc.contributor.authorCharn Sriratanasathavornen_US
dc.contributor.otherFudan Universityen_US
dc.contributor.otherChinese University of Hong Kongen_US
dc.contributor.otherKorea University Medical Centeren_US
dc.contributor.otherSarawak General Hospitalen_US
dc.contributor.otherNational Taiwan University Hospitalen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-08-24T01:58:17Z-
dc.date.available2018-08-24T01:58:17Z-
dc.date.issued2007-12-01en_US
dc.identifier.citationCurrent Medical Research and Opinion. Vol.23, No.12 (2007), 3055-3068en_US
dc.identifier.issn03007995en_US
dc.identifier.other2-s2.0-37749035087en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=37749035087&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/24672-
dc.description.abstractBackground: Most studies investigating the benefits of statins have focused on North American and European populations. This study focuses on evaluating the lipid-lowering effects of rosuvastatin and atorvastatin in Asian patients. Objectives: The DIrect Statin COmparison of LDL-C Values: an Evaluation of Rosuvastatin therapY (DISCOVERY)-Asia study is one of nine independently powered studies assessing the efficacy of starting doses of statins in achieving target lipid levels in different countries worldwide. DISCOVERY-Asia was a 12-week, randomised, open-label, parallel-group study conducted in China, Hong Kong, Korea, Malaysia, Taiwan, and Thailand. Results: A total of 1482 adults with primary hypercholesterolaemia and high cardiovascular risk (>20%/10 years, type 2 diabetes, or a history of coronary heart disease) were randomised in a 2:1 ratio to receive rosuvastatin 10 mg once daily (o.d.) or atorvastatin 10 mg o.d. The percentage of patients achieving the 1998 European Joint Task Force low-density lipoprotein cholesterol (LDL-C) goal of < 3.0 mmol/L at 12 weeks was significantly higher in the rosuvastatin group (n = 950) compared with the atorvastatin group (n = 471) (79.5 vs. 69.4%, respectively; p < 0.0001). Similar results were observed for 1998 European goals for total cholesterol (TC), and the 2003 European goals for LDL-C and TC. LDL-C and TC levels were reduced significantly more with rosuvastatin compared with atorvastatin. Both drugs were well-tolerated and the incidence and type of adverse events were similar in each group. Trials registration: The trial registry summary is available at http://www.clinicaltrials.gov/; ClinicalTrials.gov Identifier: NCT00241488 Conclusions: This 12-week study showed that the starting dose of rosuvastatin 10 mg o.d. was significantly more effective than the starting dose of atorvastatin 10 mg o.d. at enabling patients with primary hypercholesterolaemia to achieve European goals for LDL-C and TC in a largely Asian population in real-life clinical practice. The safety profile of rosuvastatin 10 mg is similar to that of atorvastatin 10 mg in the Asian population studied here, and is consistent with the known safety profile of rosuvastatin in the white population. © 2007 Librapharm Limited.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=37749035087&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleA randomised study comparing the efficacy and safety of rosuvastatin with atorvastatin for achieving lipid goals in clinical practice in Asian patients at high risk of cardiovascular disease (DISCOVERY-Asia study)en_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1185/030079907X242809en_US
Appears in Collections:Scopus 2006-2010

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