Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: Susceptibility to chloroquine, mefloquine and artemisinin of Plasmodium vivax in northwestern Thailand
Authors: Birgit Woitsch
Gunther Wernsdorfer
Kanungnit Congpuong
Chaiporn Rojanawatsirivet
Jeeraphat Sirichaisinthop
Walther H. Wernsdorfer
Medizinische Universitat Wien
Mahidol University
Thailand Ministry of Public Health
Keywords: Medicine
Issue Date: 1-Nov-2007
Citation: Wiener Klinische Wochenschrift. Vol.119, No.SUPPL. 3 (2007), 76-82
Abstract: The in vitro study had the objectives of monitoring the sensitivity of Plasmodium vivax to chloroquine and artemisinin, and to assess its baseline sensitivity to mefloquine in northwestern Thailand in an area near the border to Myanmar. The investigations were carried out in 2004 at the malaria clinics of Mae Sot, Chedi Ko and Mae Ka Sa, all in the district of Mae Sot, Province of Tak. The in vitro tests followed the method of Tasanor. Successful tests were obtained with 45 fresh isolates of P. vivax. The EC50 and EC 90 values for chloroquine were 120.9 nM and 655.7 nM, respectively, the GMCOC was 1699.7 nM. There was a significant decrease of the chloroquine sensitivity since 1998/1999. However, results of parallel investigations continue to indicate clinical-parasitological sensitivity to chloroquine. With mefloquine the EC50 and EC90 the (baseline) values were 131.6 nM and 972.6 nM, respectively, the GMCOC was 1987.0 nM. For artemisinin the EC50 and EC90 values were 8.7 nM and 105.2 nM, respectively, the GMCOC was 310.5 nM. As compared to 2002, the sensitivity of P. vivax to artemisinin has shown a slight but not significant increase. © 2007 Springer-Verlag.
ISSN: 00435325
Appears in Collections:Scopus 2006-2010

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.