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Title: Genotypic resistance mutations in treatment-naïve and treatment-experienced patients under widespread use of antiretroviral drugs in Thailand: Implications for further epidemiologic surveillance
Authors: Chonlaphat Sukasem
Vina Churdboonchart
Kanjana Sirisidthi
Suda Riengrojpitak
Sanchai Chasombat
Chotip Watitpun
Wantanich Piroj
Montip Tiensuwan
Wasun Chantratita
Mahidol University
The Bureau of AIDS TB and STIs
Keywords: Medicine
Issue Date: 9-Oct-2007
Citation: Japanese Journal of Infectious Diseases. Vol.60, No.5 (2007), 284-289
Abstract: The aims of this study were to illustrate the prevalence and determinants of mutations associated with antiretroviral drug resistance in a group of antiretroviral-naïve and treatment-experienced patients in Thailand, where antiretroviral drugs are widely used. One hundred and thirteen treatment-naïve (92 CRF01Æ and 21 subtype B patients) and 1,709 treatment-experienced patients were recruited. Genotypic resistance to antiretroviral drugs was studied by sequencing the isolated viruses. Mutation frequencies in treatment-naïve patients were reported along with those for treatment-experienced patients. The results showed that all of the patients with treatment experience showed the same pattern of genotypic resistance. The results also showed that only 14 drug-naïve patients (12.4%) carried HIV-1, with at least-one drug-resistant mutation. Moreover, four drug-naïve patients were found to carry the marker mutations for transmission of drug resistance. The most commonly found marker in drug-naïve patients was M36I/V/L (n = 90, 81.1%), which is a common natural polymorphism among HIV-1 subtype CRF01Æ individuals. In order to prevent the rapid emergence of resistant virus strains, a national program to monitor antiretroviral drug resistance should be established. We also recommend routine genotypic testing in treatment-naïve patients before starting antiretroviral therapy to prevent subtherapeutic response and viral failure.
ISSN: 13446304
Appears in Collections:Scopus 2006-2010

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