Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system
Authors: Michelle Dziejman
Davide Serruto
Vincent C. Tam
Derek Sturtevant
Pornphan Diraphat
Shah M. Faruque
M. Hasibur Rahman
John F. Heidelberg
Jeremy Decker
Li Li
Kate T. Montgomery
George Grills
Raju Kucherlapati
John J. Mekalanos
Mahidol university. Faculty of Public Health
Keywords: Genome;Virulence;Cholera pathogenesis;Open Access article
Issue Date: 1-Mar-2005
Citation: PNAS. Vol.102, No.9 (2005), 3465-3470
Abstract: Non-O1, non-O139 Vibrio cholerae can cause gastroenteritis and extraintestinal infections, but, unlike O1 and O139 strains of V. cholerae, little is known about the virulence gene content of non-O1, non-O139 strains and their phylogenetic relationship to other pathogenic V. cholerae. Comparative genomic microarray analysis of four pathogenic non-O1, non-O139 strains indicates that these strains are quite divergent from O1 and O139 strains. Genomic sequence analysis of a non-O1, non-O139 strain (AM-19226) that appeared particularly pathogenic in experimental animals suggests that this strain carries a type III secretion system (TTSS) that is related to the TTSS2 gene cluster found in a pandemic clone of Vibrio parahaemolyticus. The genes for this V. cholerae TTSS system appear to be present in many clinical and environmental non-O1, non- O139 strains, including at least one clone that is globally distributed. We hypothesize that the TTSS present in some pathogenic strains of non-O1, non-O139 V. cholerae may be involved in the virulence and environmental fitness of these strains.
Appears in Collections:PH-Article

Files in This Item:
File Description SizeFormat 
ph-ar-pornphan-2005.pdf340.21 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.