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Title: Surveillance of subtype and genetic variation of the circulating strains of HIV-1 in Thailand
Authors: Piyanot Wirachsilp
Wannee Kantakamalakul
Suporn Foongladda
Thippawan Chuenchitra
Surapol Kohriangudom
Niracha Athipanyasilp
Sombat Tanprasertsuk
Malee Gasitrong
Ruengpung Sutthent
Mahidol University
Armed Forces Research Institute of Medical Sciences, Thailand
Thailand Ministry of Public Health
Sappasitthiprasong Hospital
Keywords: Medicine
Issue Date: 1-Sep-2007
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.38, No.5 (2007), 814-827
Abstract: Two HIV-1 strains, CRF01_AE and subtype B′, were reported in Thailand during the early years of the epidemic. Recently, an intersubtype recombination of HIV-1 strain was found in Thailand. Eight-hundred and twenty-eight samples collected during years 1995-2004 from high-risk groups in Bangkok, northern, northeastern, and southern region of Thailand were studied. HIV-1 env nucleotide sequences were used for phylogenetic analysis of the circulating HIV-1 strain. By single HIV-1 region (env) genotyping, CRF01_AE was found in 97.3% and HIV-1 subtype B was found in 2.7%. A predominance of CRF01_AE was found in all geographic regions. Parallel analysis of the HIV-1 gag and env genes demonstrated that 2.1% and 4.0% of recombinant HIV-1 strains were found using p17 and p24 region sequences, respectively. The recombinant gag gene was also found in one southern isolate. Phylogenetic analysis of HIV-1 isolated from 20 provinces in 2002 suggested the northern and northeastern isolates were more related than the southern isolates which had the lowest genetic diversity of 0.13. The GPGQ V3 loop tip was also present in isolates from all regions. The molecular epidemiological data from this study may be useful for surveillance design as well as targeting prevention efforts. It also provides information regarding new antigenic regions of circulating strains responsible for the HIV-1 epidemic in Thailand.
ISSN: 01251562
Appears in Collections:Scopus 2006-2010

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