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Title: A regional cooperative clinical study of radiotherapy for cervical cancer in east and south-east Asian countries
Authors: Takashi Nakano
Shingo Kato
Jianping Cao
Juying Zhou
Raden Susworo
Nana Supriana
Shinichiro Sato
Tatsuya Ohno
Hisao Suto
Yuzuru Nakamura
Chul Koo Cho
Fuad B. Ismail
Miriam J.C. Calaguas
Rey H. de los Reyes
Yaowalak Chansilpa
Kullathom Thephamongkhol
Nguyen Ba Duc
To Anh Dung
Hirohiko Tsujii
Gunma University Faculty of Medicine
National Institute of Radiological Sciences Chiba
Soochow University
University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
Matsudo City Hospital
Saitma Medical University Faculty of Medicine
Korea Cancer Center Hospital
Hospital Universiti Kebangsaan Malaysia
St. Luke's Medical Center Quezon City
Jose R. Reyes Memorial Medical Center
Mahidol University
National Cancer Institute Hanoi
Keywords: Medicine
Issue Date: 1-Sep-2007
Citation: Radiotherapy and Oncology. Vol.84, No.3 (2007), 314-319
Abstract: Purpose: Radiotherapy differed widely in east and south-east Asia because of technical, cultural, and socio-economic differences. With the purpose of standardizing radiotherapy for cervical cancer in the region, an international clinical study was conducted. Materials and methods: Eleven institutions in eight Asian countries participated in the study. Between 1996 and 1998, 210 patients with stage IIIB cervical cancer were enrolled. Patients were treated with a combination of external beam radiotherapy (total dose, 50 Gy) and either high-dose-rate (HDR) or low-dose-rate (LDR) intracavitary brachytherapy (ICBT) according to the institutional practice. The planned point A dose was 20-28 Gy/4 fractions for HDR-ICBT and 30-40 Gy/1-2 fractions for LDR-ICBT. Results: Hundred patients were treated with HDR-ICBT and 110 were treated with LDR-ICBT. The ICBT doses actually delivered to point A ranged widely: 12-32 Gy in the HDR group and 26-52.7 Gy in the LDR group. The 5-year follow-up rate among the countries differed greatly, from 29% to 100%. The 5-year major complication rates were 6% in the HDR group and 10% in the LDR group. The 5-year overall survival rates were 51.1% in the HDR group and 57.5% in the LDR group. Conclusions: Although there were several problems with treatment compliance and patients' follow-up, the study suggests that the protocols provided favorable outcomes with acceptable rates of late complications in the treatment of advanced cervical cancer in east and south-east Asia. © 2007 Elsevier Ireland Ltd. All rights reserved.
ISSN: 01678140
Appears in Collections:Scopus 2006-2010

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