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Title: Fecal alpha1 - Antitrypsin in healthy and intestinal-disorder Thai children
Authors: Duangsmorn Tangsilsat
Kalayanee Atamasirikul
Suporn Treepongkaruna
Supranee Nathsevee
Rungtip Sumritsopak
Mongkol Kunakorn
Clinical Immunology Laboratories
Mahidol University
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Keywords: Medicine
Issue Date: 1-Jul-2007
Citation: Journal of the Medical Association of Thailand. Vol.90, No.7 (2007), 1317-1322
Abstract: Objective: Determine the normal FA1-AT level in random wet stool of Thai children using RID and NPL, and to study the correlation between RID and NPL methods for measurement of FA1-AT. Material and Method: Random stool samples were collected from healthy children and intestinal-disorders patients. Alpha1-antitrypsin (FA1-AT) in wet stool samples was measured by nephelometry (NPL) and radial-immunodiffusion (RID) methods. Results: Newborn infants had the highest FA1-AT level during the first day of life and declined to the same level as older children on day 3-4. Median and geometric mean of FA1-AT levels by NPL from healthy children aged 1 month - 15 years was 1.23 and 1.11 mg/dL respectively. FA1-AT levels by NPL from children with severe intestinal disorders, displaying median and geometric mean at 6.77 and 12.39 mg/dL respectively, were much higher than healthy children. The RID and NPL methods showed a correlation of r = 0.87 (p < 0.01) and R2 = 0.75. Conclusion: Random FA1-AT assay in wet stool is a non-invasive and simple test for supporting diagnosis of protein-losing enteropathy.
ISSN: 01252208
Appears in Collections:Scopus 2006-2010

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