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Title: TNF α and NRAMP1 polymorphisms in leprosy
Authors: Sasijit Vejbaesya
Punkae Mahaisavariya
Panpimon Luangtrakool
Chutima Sermduangprateep
Mahidol University
Keywords: Medicine
Issue Date: 1-Jun-2007
Citation: Journal of the Medical Association of Thailand. Vol.90, No.6 (2007), 1188-1192
Abstract: Objective: To determine the association of TNF α and NRAMP1 polymorphisms in leprosy. Material and Method: The polymorphisms of TNF α at -238, -308, and NRAMP1 at INT4, D543N, and 3′ UTR were examined in 37 patients with leprosy (24 multibacillary and 13 paucibacillary) and 140 healthy controls. PCR-SSP and PCR-SSO method were used to type TNF and NRAMP1 polymorphisms. Results: The genotype frequency of TNF-308 G/A was significantly increased in all leprosy patients compared to the controls (p = 0.04, OR = 2.69). When leprosy types were divided, the allele frequency of TNF-308A was significantly increased in multibacillary leprosy compared to the normal controls (p = 0.04, OR = 2.93). There was no significant difference in the distribution of the genotypes and allele frequencies of TNF -238 and NRAMP1 polymorphisms between the patients and controls. Conclusion: TNF-308A was associated with susceptibility to multibacillary leprosy.
ISSN: 01252208
Appears in Collections:Scopus 2006-2010

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