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Title: AML1 mutation and its coexistence with different transcription factor gene families in de novo acute myeloid leukemia: Redundancy or synergism
Authors: Chirayu U. Auewarakul
Amporn Leecharendkeat
Chintana Tocharoentanaphol
Orathai Promsuwicha
Narongrit Sritana
Wanna Thongnoppakhun
Mahidol University
Chulabhorn Research Institute
Keywords: Medicine
Issue Date: 1-Jun-2007
Citation: Haematologica. Vol.92, No.6 (2007), 861-862
Abstract: AML1 mutations were identified in 6.3% of AML patients with chromosomal translocations involving CBF, PML-RARĪ±, HOX, or ETS transcription factor (TF) gene families. Rare chromosomal abnormalities, t(16;21) and t(7;11), were also found. This study represents the first series to demonstrate the coexistence of known and novel AML1 mutations with different TF gene mutations. Although the occurrence of two TF gene mutations may appear unnecessary, the possible synergistic mechanism between different TF gene families cannot be excluded and needs to be further explored.
ISSN: 03906078
Appears in Collections:Scopus 2006-2010

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