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Title: Efficacy and safety of sildenafil in Asian males with erectile dysfunction and cardiovascular risk
Authors: Peera Buranakitjaroen
Ampica Mangklabruks
Somboon Leungwattanakij
Weerapatn Ngaothamatasn
Charan Malhotra
Christopher Chee
Sahabudin Raja Mohamed
Rohan Malek Dato'Johan
Mahidol University
Chiang Mai University
Hatyai Hospital
BNH Hospital
Singapore General Hospital
Kuala Lumpur Hospital
Hospital Selayang
Keywords: Medicine
Issue Date: 1-Jun-2007
Citation: Journal of the Medical Association of Thailand. Vol.90, No.6 (2007), 1100-1108
Abstract: Objective: Assess the effectiveness of sildenafil in Asian males with erectile dysfunction (ED) and one or more of the co-morbidities, mild-to-moderate hypertension, dyslipidemia, and diabetes. Material and Method: A six-week, double-blind, randomized, placebo-controlled, multicenter study was carried out in Thailand, Malaysia and Singapore One hundred and fifty five male subjects were randomized (2:1) to sildenafil (n = 104) or placebo (n = 51). Sildenafil was started at 50mg and increased (100 mg) or decreased (25mg) at week 2 if necessary. Results: On the primary efficacy endpoint, sildenafil-treated subjects had significantly better scores on the International Index of Erectile Function (IIEF) questions 3 and 4 than placebo (p < 0.001, both questions). When accumulated into IIEF domains, all five domains were significant in favor of sildenafil. In addition, sildenafil-treated subjects were more satisfied with treatment and had a higher intercourse success rate. The majority of adverse events were mild in severity; the most commonly reported treatment-related events were dizziness (7.7%) and tinnitus (2.9%). Conclusion: Sildenafil (25, 50, and 100 mg) was found to be an effective, safe, and well-tolerated treatment for ED in the present study population of Thai, Malaysian, and Singaporean males who also had increased cardiovascular risk.
ISSN: 01252208
Appears in Collections:Scopus 2006-2010

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