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Title: Differences in ablation size in porcine kidney, liver, and lung after cryoablation using the same ablation protocol
Authors: Sompol Permpongkosol
Theresa L. Nicol
Richard E. Link
Ioannis Varkarakis
Hema Khurana
Qihui Jim Zhai
Louis R. Kavoussi
Stephen B. Solomon
The Johns Hopkins School of Medicine
Mahidol University
Johns Hopkins Bayview Medical Center
Baylor College of Medicine
Methodist Hospital Houston
North Shore-Long Island Jewish Health System
Memorial Sloan-Kettering Cancer Center
Keywords: Medicine
Issue Date: 1-Apr-2007
Citation: American Journal of Roentgenology. Vol.188, No.4 (2007), 1028-1032
Abstract: OBJECTIVE. The purpose of our study was to assess the variation in size of acute necrosis and the variation in thermal map measured during cryoablation in multiple organs using the same ablation protocol for each organ. MATERIAL AND METHODS. Eight female pigs underwent one cryoablation per organ of kidney, lung, and liver performed with open surgery with a 2.4-mm cryoprobe. A 12-and 8-minute double-freeze cycle was used. Intratissue temperatures were monitored using 16-gauge thermometers spaced at 5.0-mm increments from the cryoprobe. The comparison of results among tissues was performed using the multiple analysis of variance. The -20°C thermal diameter was correlated with tissue damage. The kidneys, lungs, and liver were removed and examined histologically for a pathologic complete coagulative necrosis zone. RESULT. A single 2.4-mm cryoprobe had a mean ice ball diameter in kidney, lung, and liver of 38.5 ± 4.7, 35.5 ± 3.6, and 32.5 ± 2.7 mm, respectively. A mean -20°C thermal diameter was achieved at 24.07 ± 1.38 mm in kidney, 12.76 ± 3.0 mm in lung, and 8.8 ± 3.7 mm in liver by means of regression analysis. The acute pathologic complete coagulative necrosis zone size was 21.0 ± 1.56 mm (kidney), 11.6 ± 1.48 mm (lung), and 8.0 ± 1.20 mm (liver). CONCLUSION. The inherent characteristics of different organs manifest different ablation zone sizes during cryoablation despite the same ablation protocol being used. This information should be factored into planning for ablation procedures. © American Roentgen Ray Society.
ISSN: 0361803X
Appears in Collections:Scopus 2006-2010

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