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Title: Advances in urinary proteome analysis and biomarker discovery
Authors: Danilo Fliser
Jan Novak
Visith Thongboonkerd
Angel Argiles
Vera Jankowski
Mark A. Girolami
Joachim Jankowski
Harald Mischak
Medizinische Hochschule Hannover (MHH)
University of Alabama at Birmingham
Mahidol University
CHU Montpellier
Charité – Universitätsmedizin Berlin
University of Glasgow
Mosaiques Diagnostics and Therapeutics AG
Keywords: Medicine
Issue Date: 1-Apr-2007
Citation: Journal of the American Society of Nephrology. Vol.18, No.4 (2007), 1057-1071
Abstract: Noninvasive diagnosis of kidney diseases and assessment of the prognosis are still challenges in clinical nephrology. Definition of biomarkers on the basis of proteome analysis, especially of the urine, has advanced recently and may provide new tools to solve those challenges. This article highlights the most promising technological approaches toward deciphering the human proteome and applications of the knowledge in clinical nephrology, with emphasis on the urinary proteome. The data in the current literature indicate that although a thorough investigation of the entire urinary proteome is still a distant goal, clinical applications are already available. Progress in the analysis of human proteome in health and disease will depend more on the standardization of data and availability of suitable bioinformatics and software solutions than on new technological advances. It is predicted that proteomics will play an important role in clinical nephrology in the very near future and that this progress will require interactive dialogue and collaboration between clinicians and analytical specialists. Copyright © 2007 by the American Society of Nephrology.
ISSN: 10466673
Appears in Collections:Scopus 2006-2010

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