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Title: Immune dysfunction in HIV-seronegative, Cryptococcus gattii meningitis
Authors: Annemarie E. Brouwer
Asna A. Siddiqui
Maartje I. Kester
Kim C.E. Sigaloff
Adul Rajanuwong
Saran Wannapasni
Wirongrong Chierakul
Thomas S. Harrison
St George's University of London
Mahidol University
Radboud University Nijmegen Medical Centre
Alkmaar Medical Centre
Department of Internal Medicine
Sappasitthiprasong Hospital
Keywords: Medicine
Issue Date: 1-Mar-2007
Citation: Journal of Infection. Vol.54, No.3 (2007)
Abstract: The pathophysiology of meningitis caused by Cryptococcus gattii in apparently immunocompetent individuals remains unclear. We measured multiple cytokines in CSF from a HIV-seronegative, apparently immunocompetent, Thai patient with C. gattii meningitis, over the first 2 weeks of antifungal therapy. Levels of proinflammatory IFN-γ, TNF-α, and IL-6 were very low compared to patients with HIV-related Cryptococcus neoformans meningitis and of IL-10 very high. While patients with C. gattii meningitis may be a heterogeneous group, these data suggest in this case a maladapted immune response to cryptococcal exposure had allowed progression to clinical cryptococcal disease. © 2006 The British Infection Society.
ISSN: 01634453
Appears in Collections:Scopus 2006-2010

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