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Title: A prophylactic approach for bone marrow transplantation from a hepatitis B surface antigen-positive donor
Authors: Abhasnee Sobhonslidsuk
Artit Ungkanont
Mahidol University
Keywords: Medicine
Issue Date: 21-Feb-2007
Citation: World Journal of Gastroenterology. Vol.13, No.7 (2007), 1138-1140
Abstract: It has been accepted that bone marrow transplantation (BMT) is the only curative therapeutic option for certain hematologic malignancies. The southeast Asia region is an endemic area of hepatitis B virus (HBV) infection; thus, BMT using a hepatitis B surface antigen (HBsAg)-positive donor is occasionally unavoidable. Organ transplantation using a HBsAg-positive donor can lead to post-transplantation de novo HBV infection and severe HBV-related hepatitis if no effective prophylactic measures are taken prior to and after transplantation. In this report, a four-level approach was designed for a patient with chronic myeloid leukemia, beginning with a booster HBV vaccination before performing BMT with a HBsAg-positive donor. Prior to BMT, the HBV viral load of the donor was reduced to an undetectable level by antiviral therapy. After BMT, hepatitis B immunoglobulin was administered intramuscularly for 1 wk together with a long-term antiviral drug, lamivudine. One year after discontinuation of lamivudine, the patient is still free of HBV infection. © 2007 The WJG Press. All rights reserved.
ISSN: 10079327
Appears in Collections:Scopus 2006-2010

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