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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/24987
Title: Dysplastic nodules and small primary carcinoma of the liver: A study detecting the early morphological changes during hepatocarcinogenesis
Authors: Pattana Sornmayura
Paisan Boonsakan
Abhasnee Sobhonslidsuk
Suthus Sriphojanart
Chakrapan Euanorasetr
Sukhum Bunyaratvej
Mahidol University
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Keywords: Medicine
Issue Date: 1-Feb-2007
Citation: Journal of the Medical Association of Thailand. Vol.90, No.2 (2007), 352-362
Abstract: Objective: Detect the early histological changes relating to human hepatocarcinogenesis in three nodular hepatocellular lesions Material and Method: Three cases of dysplastic nodules and one of small hepatocellular carcinoma were obtained from the authors' surgical-pathology file during 2000-2005 for a histopathological study in relevance to the early changes during hepatocarcinogenesis by employing hematoxylin and eosin stain, as well as some immunohistochemical staining. Results: One nodular hepatocellular lesion, diagnosed as a complex lesion of focal nodular hyperplasia contained a microscopic focus (1.5 mm in diameter) of combined hepatocellular and cholangiocarcinoma. Conclusion: The small dysplastic hepatocytes subjected to neoplastic transformation combined hepatocellular and cholangiocarcinoma and are the precursorial cells of hepatocellular carcinoma. Chronic viral hepatitis B or C, aflatoxin B1 and nitrosamine(s), as well as some nodular hepatocellular lesions share distinct roles in the complex process of hepatocarcinogenesis pertaining to this Southeast Asian country.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33847692754&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/24987
ISSN: 01252208
01252208
Appears in Collections:Scopus 2006-2010

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