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dc.contributor.authorPattana Sornmayuraen_US
dc.contributor.authorPaisan Boonsakanen_US
dc.contributor.authorAbhasnee Sobhonslidsuken_US
dc.contributor.authorSuthus Sriphojanarten_US
dc.contributor.authorChakrapan Euanorasetren_US
dc.contributor.authorSukhum Bunyaratvejen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
dc.identifier.citationJournal of the Medical Association of Thailand. Vol.90, No.2 (2007), 352-362en_US
dc.description.abstractObjective: Detect the early histological changes relating to human hepatocarcinogenesis in three nodular hepatocellular lesions Material and Method: Three cases of dysplastic nodules and one of small hepatocellular carcinoma were obtained from the authors' surgical-pathology file during 2000-2005 for a histopathological study in relevance to the early changes during hepatocarcinogenesis by employing hematoxylin and eosin stain, as well as some immunohistochemical staining. Results: One nodular hepatocellular lesion, diagnosed as a complex lesion of focal nodular hyperplasia contained a microscopic focus (1.5 mm in diameter) of combined hepatocellular and cholangiocarcinoma. Conclusion: The small dysplastic hepatocytes subjected to neoplastic transformation combined hepatocellular and cholangiocarcinoma and are the precursorial cells of hepatocellular carcinoma. Chronic viral hepatitis B or C, aflatoxin B1 and nitrosamine(s), as well as some nodular hepatocellular lesions share distinct roles in the complex process of hepatocarcinogenesis pertaining to this Southeast Asian country.en_US
dc.rightsMahidol Universityen_US
dc.titleDysplastic nodules and small primary carcinoma of the liver: A study detecting the early morphological changes during hepatocarcinogenesisen_US
Appears in Collections:Scopus 2006-2010

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