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Title: Antimalarial drugs and pregnancy: safety, pharmacokinetics, and pharmacovigilance
Authors: Stephen A. Ward
Esperanca JP Sevene
Ian M. Hastings
François Nosten
Rose McGready
Liverpool School of Tropical Medicine
University of Maputo
Shoklo Malaria Research Unit
Mahidol University
John Radcliffe Hospital
Keywords: Medicine
Issue Date: 1-Feb-2007
Citation: Lancet Infectious Diseases. Vol.7, No.2 (2007), 136-144
Abstract: Before a recommendation for antimalarial drug use in pregnancy is made, it is essential that we understand the potential risks involved and have mechanisms in place to monitor risk during treatment. This requires data on drug disposition during pregnancy and potential toxicological liabilities to the developing fetus and mother. In most cases this information is not available. We review the reproductive toxicology of the main antimalarial drug classes in use or under development. Preclinical data are presented if appropriate, but as human experience overrides such data, in instances in which preclinical studies do not correlate with the human experience the data are reviewed only briefly. Additionally, we highlight the lack of appropriate drug disposition data in pregnancy and suggest mechanisms that can be used to capture data on risk after drug treatment in pregnancy. © 2007 Elsevier Ltd. All rights reserved.
ISSN: 14733099
Appears in Collections:Scopus 2006-2010

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