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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/25015
Title: Molecular analysis of Mycobacterium tuberculosis causing multidrug-resistant tuberculosis meningitis
Authors: Maxine Caws
G. E. Thwaites
P. M. Duy
D. Q. Tho
N. T. Ngoc Lan
D. V. Hoa
T. T. Hong Chau
M. N. Thu Huyen
P. T. Hoang Anh
N. V.V. Chau
N. T. Chinh
K. Stepniewska
J. Farrar
University of Oxford
Churchill Hospital
Brighton and Sussex University Hospitals NHS Trust
Pham Ngoc Thach Hospital for Tuberculosis and Lung Diseases
UCL
Mahidol University
Keywords: Medicine
Issue Date: 1-Feb-2007
Citation: International Journal of Tuberculosis and Lung Disease. Vol.11, No.2 (2007), 202-208
Abstract: SETTING: Tertiary referral hospitals in southern Vietnam. OBJECTIVE: Molecular characterisation of multidrug-resistant (MDR) tuberculous meningitis (TBM). DESIGN: Mycobacterium tuberculosis isolates from the cerebrospinal fluid (CSF) of 198 Vietnamese adults were compared with 237 isolates from patients with pulmonary tuberculosis (PTB) matched for age, sex and residential district. Isolates resistant to isoniazid or rifampicin (RMP) were sequenced in the rpoB and katG genes, inhA promoter and oxyR-ahpC intergenic regions. RESULTS: While drug resistance rates were lower in the CSF (2.5% MDR) than pulmonary isolates (5.9% MDR), the difference was not significant. The most commonly mutated codons were 531, 526 and 516 in rpoB and 315 in katG. Four novel triple mutants in rpoB were identified. CONCLUSION: RMP resistance is a good surrogate marker for MDR-TBM in this setting. However, probes directed against these three codons would have a maximum sensitivity of only 65%. A rapid phenotypic detection test may be more applicable for the diagnosis of MDR-TBM. © 2007 The Union.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33846861289&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/25015
ISSN: 10273719
Appears in Collections:Scopus 2006-2010

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