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Title: Apoptosis and pathogenesis of avian influenza A (H5N1) virus in humans
Authors: Mongkol Uiprasertkul
Rungrueng Kitphati
Pilaipan Puthavathana
Romchat Kriwong
Alita Kongchanagul
Kumnuan Ungchusak
Suwimon Angkasekwinai
Kulkanya Chokephaibulkit
Kanittar Srisook
Nirun Vanprapar
Prasert Auewarakul
Mahidol University
Thailand Ministry of Public Health
Phaholpolphayuhasena Hospital
Keywords: Medicine
Issue Date: 1-Jan-2007
Citation: Emerging Infectious Diseases. Vol.13, No.5 (2007), 708-712
Abstract: The pathogenesis of avian influenza A (H5N1) virus in humans has not been clearly elucidated. Apoptosis may also play an important role. We studied autopsy specimens from 2 patients who died of infection with this virus. Apoptosis was observed in alveolar epithelial cells, which is the major target cell type for the viral replication. Numerous apoptotic leukocytes were observed in the lung of a patient who died on day 6 of illness. Our data suggest that apoptosis may play a major role in the pathogenesis of influenza (H5N1) virus in humans by destroying alveolar epithelial cells. This pathogenesis causes pneumonia and destroys leukocytes, leading to leukopenia, which is a prominent clinical feature of influenza (H5N1) virus in humans. Whether observed apoptotic cells were a direct result of the viral replication or a consequence of an overactivation of the immune system requires further studies.
ISSN: 10806059
Appears in Collections:Scopus 2006-2010

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