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|Title:||Release of granzymes and chemokines in Thai patients with leptospirosis|
|Authors:||M. De Fost|
N. J. White
T. Van Der Poll
Academic Medical Centre, University of Amsterdam
Udon Thani Regional Hospital
University of Oxford
|Citation:||Clinical Microbiology and Infection. Vol.13, No.4 (2007), 433-436|
|Abstract:||The plasma concentrations of granzymes are considered to reflect the involvement of cytotoxic T-cells and natural killer cells in various disease states. Interferon (IFN)-γ-inducible protein-10 (IP-10) and monokine induced by IFN-γ (Mig) are members of the non-ELR CXC chemokine family that act on T-cells and natural killer cells. This study revealed that the plasma concentrations of granzyme B (but not granzyme A), IP-10 and Mig were higher in 44 Thai patients with definite or possible leptospirosis than in healthy blood donors. These data suggest that activation of cell-mediated immunity is part of the early host response to leptospirosis. © 2007 European Society of Clinical Microbiology and Infectious Diseases.|
|Appears in Collections:||Scopus 2006-2010|
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