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Title: Release of granzymes and chemokines in Thai patients with leptospirosis
Authors: M. De Fost
W. Chierakul
R. Limpaiboon
A. Dondorp
N. J. White
T. Van Der Poll
Academic Medical Centre, University of Amsterdam
Mahidol University
Udon Thani Regional Hospital
University of Oxford
Keywords: Medicine
Issue Date: 1-Jan-2007
Citation: Clinical Microbiology and Infection. Vol.13, No.4 (2007), 433-436
Abstract: The plasma concentrations of granzymes are considered to reflect the involvement of cytotoxic T-cells and natural killer cells in various disease states. Interferon (IFN)-γ-inducible protein-10 (IP-10) and monokine induced by IFN-γ (Mig) are members of the non-ELR CXC chemokine family that act on T-cells and natural killer cells. This study revealed that the plasma concentrations of granzyme B (but not granzyme A), IP-10 and Mig were higher in 44 Thai patients with definite or possible leptospirosis than in healthy blood donors. These data suggest that activation of cell-mediated immunity is part of the early host response to leptospirosis. © 2007 European Society of Clinical Microbiology and Infectious Diseases.
ISSN: 14690691
Appears in Collections:Scopus 2006-2010

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