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Title: Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes
Authors: Mullika Traidej Chomnawang
Suvimol Surassmo
Veena S. Nukoolkarn
Wandee Gritsanapan
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Sep-2007
Citation: Fitoterapia. Vol.78, No.6 (2007), 401-408
Abstract: The present study was aimed to investigate the activity of Thai medicinal plants on inflammation caused by Propionibacterium acnes in terms of free radical scavenging and cytokine reducing properties. P. acnes have been recognized as pus-forming bacteria triggering an inflammation in acne. Antioxidant activity was determined by DPPH scavenging and NBT reduction assay. The result showed that Garcinia mangostana possessed the most significant antioxidant activity and reduced reactive oxygen species production. Houttuynia cordata, Eupatorium odoratum, and Senna alata had a moderate antioxidant effect. In addition, Garcinia mangostana extracts could reduce the TNF-α production as determined by ELISA. Garcinia mangostana was highly effective in scavenging free radicals and was able to suppress the production of pro-inflammatory cytokines. This study has identified the promising source of anti-inflammatory agent which could be useful in treatment of acne vulgaris. © 2007 Elsevier B.V. All rights reserved.
ISSN: 0367326X
Appears in Collections:Scopus 2006-2010

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