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Title: Antiproliferative effect of Erycibe elliptilimba on human breast cancer cell lines
Authors: Tanawan Kummalue
Pornchai O-charoenrat
Weena Jiratchariyakul
Monraudee Chanchai
Kovit Pattanapanyasat
Kasama Sukapirom
Surat Iemsri
Faculty of Medicine, Siriraj Hospital, Mahidol University
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 4-Apr-2007
Citation: Journal of Ethnopharmacology. Vol.110, No.3 (2007), 439-443
Abstract: Erycibe elliptilimba Merr. & Chun., family Convolvulaceae, is a Thai traditional medicine which has long been prescribed for various infectious and malignant diseases. Bio-assays of extracts from Erycibe elliptilimba Merr. & Chun. showed that a fraction (fraction 3) from an methanolic extract had an antiproliferative effect on SKBR3 and MDA-MB435 human breast cancer cells. The ED50 value of Erycibe elliptilimba Merr. & Chun. fraction 3 was 56.07 and 30.61 μg/ml for SKBR3 and MDA-MB435, respectively. After 48 h of exposure, this fraction at a concentration of 100 μg/ml significantly reduced cell proliferation in both cancer cells. In MDA-MB435 cells, cell cycle analysis showed that the herb extract fraction 3 induced the accumulation of cells in G2/M phase, whereas no significant change in cell cycle was detected in SKBR3 cells. The results indicated that the extract fraction 3 could induce cell cycle arrest in some way. However, further investigation is needed to assess the molecular mechanisms mediated anticancer activities of this plant. © 2006 Elsevier Ireland Ltd. All rights reserved.
ISSN: 03788741
Appears in Collections:Scopus 2006-2010

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