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Title: Seroprevalence of human herpesvirus-8 (HHV-8) in countries of Southeast Asia compared to the USA, the Caribbean and Africa
Authors: D. Ablashi
L. Chatlynne
H. Cooper
D. Thomas
M. Yadav
A. W. Norhanom
A. K. Chandana
V. Churdboonchart
S. A.R. Kulpradist
M. Patnaik
K. Liegmann
R. Masood
M. Reitz
F. Cleghorn
A. Manns
P. H. Levine
C. Rabkin
R. Biggar
F. Jensen
P. Gill
N. Jack
J. Edwards
J. Whitman
C. Boshoff
Advanced Biotechnologies Inc.
University of Malaya
Mahidol University
Specialty Laboratories
University of Southern California
University of Maryland, Baltimore
National Cancer Institute
George Washington University School of Medicine and Health Sciences
Orchestra Therapeutics Inc
Med. Res. Found. of Trinidad and T.
Chester Beatty Research Institute
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 9-Nov-1999
Citation: British Journal of Cancer. Vol.81, No.5 (1999), 893-897
Abstract: Seroprevalence of HHV-8 has been studied in Malaysia, India, Sri Lanka, Thailand, Trinidad, Jamaica and the USA, in both healthy individuals and those infected with HIV. Seroprevalence was found to be low in these countries in both the healthy and the HIV-infected populations. This correlates with the fact that hardly any AIDS-related Kaposi's sarcoma has been reported in these countries. In contrast, the African countries of Ghana, Uganda and Zambia showed high seroprevalences in both healthy and HIV-infected populations. This suggests that human herpes virus-8 (HHV-8) may be either a recently introduced virus or one that has extremely low infectivity. Nasopharyngeal and oral carcinoma patients from Malaysia, Hong Kong and Sri Lanka who have very high EBV titres show that only 3/82 (3.7%) have antibody to HHV-8, demonstrating that there is little, if any, cross-reactivity between antibodies to these two gamma viruses.
ISSN: 00070920
Appears in Collections:Scopus 1991-2000

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