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dc.contributor.authorChristine Mcmahonen_US
dc.contributor.authorTuangporn Suthiphongchaien_US
dc.contributor.authorJames Direnzoen_US
dc.contributor.authorMark E. Ewenen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherDana-Farber Cancer Instituteen_US
dc.contributor.otherHarvard Medical Schoolen_US
dc.date.accessioned2018-09-07T08:48:21Z-
dc.date.available2018-09-07T08:48:21Z-
dc.date.issued1999-05-11en_US
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America. Vol.96, No.10 (1999), 5382-5387en_US
dc.identifier.issn00278424en_US
dc.identifier.other2-s2.0-0033545929en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033545929&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/25341-
dc.description.abstractCyclin D1 is overexpressed in a significant percentage of human breast cancers, particularly in those that also express the estrogen receptor (ER). We and others have demonstrated previously that experimentally overexpressed cyclin D1 can associate with the ER and stimulate its transcriptional functions in the absence of estrogen. This effect is separable from the established function of cyclin D1 as a regulator of cyclin-dependent kinases. Here, we demonstrate that cyclin D1 can also interact with the histone acetyltransferase, p300/CREB-binding protein-associated protein (P/CAF), thereby facilitating an association between P/CAF and the ER. Ectopic expression of P/CAF potentiates cyclin D1-stimulated ER activity in a dose- dependent manner. This effect is largely dependent on the acetyltransferase activity of P/CAF. These results suggest that cyclin D1 may trigger the activation of the ER through the recruitment of P/CAF, by providing histone acetyltransferase activity and, potentially, links to additional P/CAF- associated transcriptional coactivators.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033545929&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMultidisciplinaryen_US
dc.titleP/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptoren_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1073/pnas.96.10.5382en_US
Appears in Collections:Scopus 1991-2000

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