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Title: P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor
Authors: Christine Mcmahon
Tuangporn Suthiphongchai
James Direnzo
Mark E. Ewen
Mahidol University
Dana-Farber Cancer Institute
Harvard Medical School
Keywords: Biochemistry, Genetics and Molecular Biology;Multidisciplinary
Issue Date: 11-May-1999
Citation: Proceedings of the National Academy of Sciences of the United States of America. Vol.96, No.10 (1999), 5382-5387
Abstract: Cyclin D1 is overexpressed in a significant percentage of human breast cancers, particularly in those that also express the estrogen receptor (ER). We and others have demonstrated previously that experimentally overexpressed cyclin D1 can associate with the ER and stimulate its transcriptional functions in the absence of estrogen. This effect is separable from the established function of cyclin D1 as a regulator of cyclin-dependent kinases. Here, we demonstrate that cyclin D1 can also interact with the histone acetyltransferase, p300/CREB-binding protein-associated protein (P/CAF), thereby facilitating an association between P/CAF and the ER. Ectopic expression of P/CAF potentiates cyclin D1-stimulated ER activity in a dose- dependent manner. This effect is largely dependent on the acetyltransferase activity of P/CAF. These results suggest that cyclin D1 may trigger the activation of the ER through the recruitment of P/CAF, by providing histone acetyltransferase activity and, potentially, links to additional P/CAF- associated transcriptional coactivators.
ISSN: 00278424
Appears in Collections:Scopus 1991-2000

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