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Title: Effects of temperature and humidity on the physical properties of piroxicam tablets
Authors: Narong Sarisuta
Tassanee Thamsakdakorn
Somboon Jateteela
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 28-Apr-1999
Citation: Pharmaceutical Technology. Vol.23, No.4 (1999)
Abstract: The authors studied piroxicam tablets containing various proportions of filler (lactose or mannitol) after storage for 12 weeks of 40 °C and 52% relative humidity (RH) and at 40°C and 96% RH. The tablets were prepared by wet granulation using providone as a binder. They were compressed at forces of 500-600 kg for hardness values of 6-7 kg and stored in a controlled environmental chamber. Physical properties of the tablets such as weight, thickness, hardness, loss on drying, disintegration, and dissolution were assessed every 2 weeks. This article discusses the methods used to conduct the studies and the results.
ISSN: 01478087
Appears in Collections:Scopus 1991-2000

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