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Title: Resveratrol tetramers from Vatica diospyroides
Authors: Eun Kyoung Seo
Heebyung Chai
Howard L. Constant
Thawatchai Santisuk
Vichai Reutrakul
Christopher W W Beecher
Norman R. Farnsworth
Geoffrey A. Cordell
John M. Pezzuto
A. Douglas Kinghorn
University of Illinois at Chicago
The Forest Herbarium, Thailand Ministry of Natural Resources and Environment
Mahidol University
RTI International
Bristol-Myers Squibb
Keywords: Chemistry
Issue Date: 17-Sep-1999
Citation: Journal of Organic Chemistry. Vol.64, No.19 (1999), 6976-6983
Abstract: Vatdiospyroidol (1), a novel cytotoxic resveratrol tetramer, was isolated from the stems of Vatica diospyroides Sym. (Dipterocarpaceae) by bioassay-guided fractionation monitored with a human oral epidermoid carcinoma (KB) cell line. Another novel resveratrol tetramer, vaticaphenol A (2), was obtained as a noncytotoxic constituent, along with the known compounds, bergenin, betulin, betulinic acid, mangiferonic acid, and (E)- resveratrol 3-O-β-D-glucopyranoside. The structures of compounds 1 and 2 were elucidated by spectral analysis, including 1D and 2D NMR experiments, and by molecular modeling.
ISSN: 00223263
Appears in Collections:Scopus 1991-2000

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