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Title: Antineutrophil cytoplasmic antibody (ANCA) and rapidly progressive crescentic glomerulonephritis in Thai population
Authors: Vasant Sumethkul
Siribha Changsirikulchai
Piyanuch Radinahamed
Panas Chalermsanyakorn
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Dec-1999
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.17, No.4 (1999), 281-287
Abstract: The impact of vasculitis as a cause of primary rapidly progressive crescentic glomerulonephritis (RPGN) was examined in patients with Thai ethnic by antineutrophil cytoplasmic antibody (ANCA) test. Thirty patients found in a six years study period were included. Patients' mean age was 34.8 ± 16.4 years. Mean crescent score was 86.2 ± 22.9%. ANCA proved positive in fifteen patients. This helps to differentiate vasculitis associated (ANCA positive) from nonvasculitis (ANCA negative) RPGN. Incidence of immune complex type RPGN (46.6%) is higher than the Caucasians while the incidence of antiglomerular basement membrane antibody (anti-GBM disease) is much lower. More vasculitis patients were treated with cyclophosphamide (n = 11) than the nonvasculitis group (n = 2). Mean renal survival time of ANCA and non-ANCA associated patients were 26.69 and 14.16 months, respectively. Renal survival of all patients is significantly worse if associated with a high entry creatinine (> 6 mg/dl). Our results show that vasculitis associated RPGN is not an uncommon disease in the Thai population and can be recognized initially by ANCA test.
ISSN: 0125877X
Appears in Collections:Scopus 1991-2000

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