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Title: Maternal viral load and vertical transmission of HIV-1 in mid-trimester gestation
Authors: Winit Phuapradit
Panyu Panburana
Adithep Jaovisidha
Nongluxana Vichitphun
Pahsuvadn Kongsin
Wasun Chantratita
Pisamai Bhodhiphala
Wantanit Pairoj
Vajira Hospital
Mahidol University
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 11-Nov-1999
Citation: AIDS. Vol.13, No.14 (1999), 1927-1931
Abstract: Background: It is now accepted that the majority of HIV-1 vertical transmissions occur in late gestation and at the time of delivery. However, there is wide variation in the prevalence rate of mid-trimester vertical transmission. We assessed the maternal HIV-1 RNA viral load and in utero transmission during mid-trimester gestation. Methods: Patients were enrolled when they decided to have their pregnancies terminated between 17 and 24 weeks of gestation. Prostaglandin-induced abortion with PGE1 analogue vaginal administration was carried out in all patients. Maternal plasma HIV-1 RNA viral load and plasma HIV-1 RNA (qualitative) from abortus heart blood were assessed. Results: Amongst 41 HIV-1 seropositive pregnant women not receiving antiretroviral therapy plasma HIV-1 RNA was detected in the abortus heart blood from two women (4.9%; 95% confidence interval (CI), 0.6-16.5). Transmission occurred in one out of nine (11.1%; 95% CI, 0.3-48.2) with maternal viral load ≥ 100,000 copies/ml versus one out of 32 (3.1%; 95% CI, 0.1-16.2) of those with < 100,000 copies/ml (P = 0.39). Conclusions: The frequency of HIV-1 vertical transmission during mid-trimester was approximately 5% as detected by plasma HIV-1 RNA (qualitative) method in the fetuses aborted from the prostaglandin termination of pregnancy. During mid-trimester gestation there was no correlation between high maternal viral load and vertical transmission.
ISSN: 02699370
Appears in Collections:Scopus 1991-2000

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