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Title: The eosinophilic response and haematological recovery after treatment for Plasmodium falciparum malaria
Authors: Luis H. Camacho
Polarat Wilairatana
Günter Weiss
Marco A. Mercader
Gary M. Brittenham
Sornchai Looareesuwan
Victor R. Gordeuk
George Washington University Medical Center
Mahidol University
University Hospital Innsbruck
Columbia University, College of Physicians and Surgeons
Memorial Sloan-Kettering Cancer Center
Keywords: Immunology and Microbiology;Medicine
Issue Date: 16-Aug-1999
Citation: Tropical Medicine and International Health. Vol.4, No.7 (1999), 471-475
Abstract: To examine a possible relationship between the immune response and haematological recovery after acute falciparum malaria, we followed peripheral blood eosinophil counts and haemoglobin concentrations for 4 weeks after starting effective treatment in 70 adult Thai patients. Eosinophils are induced by Th-2 cytokines as well as other stimuli. Eosinophil counts were elevated in only 8 (11%) of the subjects at presentation, but were increased in 65 (93%) by day 7. Eosinophil counts then decreased markedly by day 14, followed by a second increase until day 28. A significant positive correlation was found between peak eosinophil counts on day 7 and the haemoglobin concentration on day 28, both in 16 subjects without stool parasites (r = 0.65, P = 0.006) and in 54 patients with stool parasites (r = 0.32; P = 0.0019). These results suggest that a robust eosinophilic response shortly after completing antimalarial therapy predicts a good recovery from malaria-associated anaemia.
ISSN: 13602276
Appears in Collections:Scopus 1991-2000

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