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|Title:||Role of maternal humoral immunity in vertical transmission of HIV-1 subtype E in Thailand|
T. D. Mastro
G. P. Taylor
J. N. Weber
Imperial College London
Centers for Disease Control and Prevention
Bamrasnaradura Infectious Disease Institute
|Keywords:||Immunology and Microbiology;Medicine|
|Citation:||Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. Vol.21, No.4 (1999), 259-265|
|Abstract:||The significance of the maternal humoral immune response in relation to vertical transmission of HIV-1 was investigated in 123 mothers infected with subtype E from Thailand. Antibody binding titers to HIV-1 env domains (monomeric gp120, the CD4/gp120 binding site [BS], V3 loop, and gp41) and antibody-mediated neutralization of primary and T-cell line-adapted (TCLA) subtypes B and E HIV-1 isolates were investigated. No correlation between maternal anti HIV-1 antibodies at delivery and vertical transmission of HIV- 1 subtype E was found. However, a trend to higher titer antibody-mediated cross-neutralization of a heterologous subtype B TCLA isolate, HIV-1(MN), was observed in nontransmitting mothers postpartum. The HIV-1-specific antibody titers in these infected mothers increased significantly from delivery to 6 months postpartum (p < .05), but this was only partially attributable to hemodilution and an additional factor or factors appear to affect humoral immunity to HIV-1 during late pregnancy.|
|Appears in Collections:||Scopus 1991-2000|
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