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|Title:||Primary infection of human herpesvirus 6 in children with vertical infection of human immunodeficiency virus type 1|
Charoen Krung Pracharak Hospital
Osaka University Faculty of Medicine
National Institute of Infectious Diseases
|Keywords:||Immunology and Microbiology;Medicine|
|Citation:||Journal of Infectious Diseases. Vol.180, No.1 (1999), 50-55|
|Abstract:||The role of human herpesvirus 6 (HHV-6) infection in 227 children born to human immunodeficiency virus (HIV)-seropositive mothers was investigated. Of 41 HIV-uninfected infants, 3 (7%) were positive for HHV-6 DNA in the first month of life, suggesting possible intrauterine infection. The cumulative infection rates of HHV-6 at 6 and 12 months of age were significantly lower in HIV-infected children (11% and 33%, respectively) than in uninfected children (28% and 78%, respectively; P < .001). There was an association between high CD4+cell numbers (>15%) before HHV-6 infection and high HHV-6 infection rate. Twenty-two infants with HIV classed as Centers for Disease Control and Prevention stages N1 or N2 were studied for an association of HHV-6 infection with progression of HIV disease. Ten of the infants had HHV- 6, and 12 did not. In 5 of the infants without HHV-6 (42%), HIV disease had not progressed by 1 year of age; however, HIV disease had progressed in all 10 children with HHV-6 infection. These results suggest an association of HHV-6 infection and progression of HIV disease in the study children with vertical HIV-1 infection (P < .05).|
|Appears in Collections:||Scopus 1991-2000|
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