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Title: Primary infection of human herpesvirus 6 in children with vertical infection of human immunodeficiency virus type 1
Authors: Uraiwan Kositanont
Chantapong Wasi
Nirun Wanprapar
Piyaporn Bowonkiratikachorn
Kulkunya Chokephaibulkit
Sanay Chearskul
Kanittha Chimabutra
Ruengpung Sutthent
Suporn Foongladda
Reiko Inagi
Takeshi Kurata
Koichi Yamanishi
Mahidol University
Charoen Krung Pracharak Hospital
Osaka University Faculty of Medicine
National Institute of Infectious Diseases
Keywords: Immunology and Microbiology;Medicine
Issue Date: 5-Jul-1999
Citation: Journal of Infectious Diseases. Vol.180, No.1 (1999), 50-55
Abstract: The role of human herpesvirus 6 (HHV-6) infection in 227 children born to human immunodeficiency virus (HIV)-seropositive mothers was investigated. Of 41 HIV-uninfected infants, 3 (7%) were positive for HHV-6 DNA in the first month of life, suggesting possible intrauterine infection. The cumulative infection rates of HHV-6 at 6 and 12 months of age were significantly lower in HIV-infected children (11% and 33%, respectively) than in uninfected children (28% and 78%, respectively; P < .001). There was an association between high CD4+cell numbers (>15%) before HHV-6 infection and high HHV-6 infection rate. Twenty-two infants with HIV classed as Centers for Disease Control and Prevention stages N1 or N2 were studied for an association of HHV-6 infection with progression of HIV disease. Ten of the infants had HHV- 6, and 12 did not. In 5 of the infants without HHV-6 (42%), HIV disease had not progressed by 1 year of age; however, HIV disease had progressed in all 10 children with HHV-6 infection. These results suggest an association of HHV-6 infection and progression of HIV disease in the study children with vertical HIV-1 infection (P < .05).
ISSN: 00221899
Appears in Collections:Scopus 1991-2000

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