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Title: Willingness of injection drug users to participate in an HIV vaccine efficacy trial in Bangkok, Thailand
Authors: Kathleen M. MacQueen
Suphak Vanichseni
Dwip Kitayaporn
Lillian S. Lin
Aumphornpun Buavirat
Thananda Naiwatanakul
Suwanee Raktham
Philip Mock
William L. Heyward
Don C. Des Jarlais
Kachit Choopanya
Timothy D. Mastro
National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
Bangkok Metropolitan Administration
Mahidol University
HIV/AIDS Collaboration
Beth Israel Medical Center
Centers for Disease Control and Prevention
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jul-1999
Citation: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. Vol.21, No.3 (1999), 243-251
Abstract: We assessed willingness to participate in an HIV recombinant gp120 bivalent subtypes B/E candidate vaccine efficacy trial among 193 injection drag users (IDUs) attending drag treatment clinics in Bangkok, Thailand. IDUs previously enrolled in a prospective cohort study were invited to group sessions describing a potential trial, then completed questionnaires assessing comprehension and willingness to participate. A week later, they completed a follow-up questionnaire that again assessed comprehension and willingness to participate, as well as barriers to and positive motives for participation, with whom (if anyone) they talked about the information, and whether others thought participation was a good, bad, or neutral idea. At baseline, 51% were definitely willing to participate, and at follow-up 54%; only 3% were not willing to participate at either time. Comprehension was high at baseline and improved at follow-up. Participants who viewed altruism, regular HIV tests, and family support for participation as important were more willing to volunteer. Frequency of incarceration and concerns about the length of the trial, possible vaccine-induced accelerated disease progression, and lack of family support were negatively associated with willingness. Overall, IDUs comprehended the information needed to make a fully informed decision about participating in an rgp120 vaccine efficacy trial and expressed a high level of willingness to participate in such a trial.
ISSN: 10779450
Appears in Collections:Scopus 1991-2000

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