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dc.contributor.authorA. Brockmanen_US
dc.contributor.authorR. E.L. Paulen_US
dc.contributor.authorT. J.C. Andersonen_US
dc.contributor.authorI. Hackforden_US
dc.contributor.authorL. Phaiphunen_US
dc.contributor.authorS. Looareesuwanen_US
dc.contributor.authorF. Nostenen_US
dc.contributor.authorK. P. Dayen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherInstitut Pasteur, Parisen_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationAmerican Journal of Tropical Medicine and Hygiene. Vol.60, No.1 (1999), 14-21en_US
dc.description.abstractParasite genotyping by the polymerase chain reaction was used to distinguish recrudescent from newly acquired Plasmodium falciparum infections in a Karen population resident on the northwestern border of Thailand where malaria transmission is low (one infection/person/year). Plasmodium falciparum infections were genotyped for allelic variation in three polymorphic antigen loci, merozoite surface proteins-1 and -2 (MSP-1 and -2) and glutamate-rich protein (GLURP), before and after antimalarial drug treatment. Population genotype frequencies were measured to provide the baseline information to calculate the probability of a new infection with a different or the same genotype to the initial pretreatment isolate. Overall, 38% of the infections detected following treatment had an identical genotype before and up to 121 days after treatment. These post-treatment genotypes were considered recrudescent because of the low (≤ 5%) probability of repeated occurrence by chance in the same patient. This approach allows studies of antimalarial drug treatment to be conducted in areas of low transmission since recrudescences can be distinguished confidently from newly acquired infections.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleApplication of genetic markers to the identification of recrudescent Plasmodium falciparum infections on the northwestern border of Thailanden_US
Appears in Collections:Scopus 1991-2000

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