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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/25469
Title: A randomized, double-blind, comparative trial of a new oral combination of artemether and benflumetol (CGP 56697) with mefloquine in the treatment of acute Plasmodium falciparum malaria in Thailand
Authors: S. Looareesuwan
P. Wilairatana
W. Chokejindachai
K. Chalermrut
W. Wernsdorfer
B. Gemperli
I. Gathmann
C. Royce
Mahidol University
Universitat Wien
Novartis International AG
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-1999
Citation: American Journal of Tropical Medicine and Hygiene. Vol.60, No.2 (1999), 238-243
Abstract: CGP 56697, a new oral fixed combination of artemether and benflumetol, was tested in a double-blinded, randomized trial in 252 adult patients treated either with CGP 56697 (4 x 4 tablets each containing 20 mg of artemether and 120 mg of benflumetol, given at 0, 8, 24, and 48 hr), or with mefloquine (three tablets of 250 mg at initial diagnosis, followed by two tablets of 250 mg at 8 hr). Baseline data of the two groups were comparable. The 28-day cure rate with CGP 56697 was lower than with mefloquine (69.3% versus 82.4%; P = 0.002). However, CGP 56697 was more effective than mefloquine in parasite clearance time (43 hr versus 66 hr; P < 0.001) fever clearance time (32 hr versus 54 hr; P < 0.005), and gametocyte clearance time (152 hr versus 331 hr; P < 0.001). This study revealed that CGP 56697 is effective against multidrug-resistant Plasmodium falciparum malaria in Thailand, but higher doses will probably be needed to improve the cure rate.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033048031&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/25469
ISSN: 00029637
Appears in Collections:Scopus 1991-2000

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