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dc.contributor.authorR. E.L. Paulen_US
dc.contributor.authorA. Brockmanen_US
dc.contributor.authorR. N. Priceen_US
dc.contributor.authorC. Luxemburgeren_US
dc.contributor.authorN. J. Whiteen_US
dc.contributor.authorS. Looareesuwanen_US
dc.contributor.authorF. Nostenen_US
dc.contributor.authorK. P. Dayen_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherJohn Radcliffe Hospitalen_US
dc.contributor.otherInstitut Pasteur, Parisen_US
dc.identifier.citationTransactions of the Royal Society of Tropical Medicine and Hygiene. Vol.93, No.6 (1999), 587-593en_US
dc.description.abstractGenetic characterization of Plasmodium falciparum infections in north-western Thailand, a region of low transmission intensity (1 infection/person each year), has found a comparable number of parasite genotypes per infected person to regions with hyperendemic malaria. Clone multiplicity and parasite diversity were found to be homogeneous across 129 infected individuals comprising a range of age-groups (1.32 parasite genotypes; n = 98), patients (aged 2-16 years) with recrudescent infections (1.54; n = 13), and pregnant women (1.61; n = 18). Individuals belonging to groups with a high risk of infection, as deduced by clinical epidemiology, did not harbour a higher number of clones per infection, nor greater parasite diversity than low-risk groups. In fact, multiple genotype infections were as common in low-risk groups, suggesting that there is frequent transmission of polyclonal infections from a single inoculum, rather than superinfection. Such a polyclonal transmission system would enable generation of extensive parasite diversity by recombination, despite the low level of transmission. However, co-infection with P. vivax was associated with fewer P. falciparum genotypes per infection.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleGenetic analysis of Plasmodium falciparum infections on the north-western border of Thailanden_US
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