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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/25477
Title: Risk factors for gametocyte carriage in uncomplicated falciparum malaria
Authors: Ric Price
François Nosten
Julie A. Simpson
Christine Luxemburger
Lucy Phaipun
Feiko Ter Kuile
Michele Van Vugt
Tan Chongsuphajaisiddhi
Nicholas J. White
John Radcliffe Hospital
Shoklo Malaria Research Unit
Mahidol University
Kenya Medical Research Institute
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-1999
Citation: American Journal of Tropical Medicine and Hygiene. Vol.60, No.6 (1999), 1019-1023
Abstract: The factors affecting the development of patent Plasmodium falciparum gametocytemia were assessed in 5,682 patients entered prospectively into a series of antimalarial drug trials conducted in an area of low and seasonal transmission on the western border of Thailand. Of the 4,565 patients with admission thick smear assessments, 110 (2.4%) had gametocytemia. During the follow-up period 170 (3%) of all patients developed patent gametocytemia, which in 89% had developed by day 14 following treatment. In a multiple logistic regression model five factors were found to be independent risk factors at presentation for the development or persistence of gametocytemia during follow up; patent gametocytemia on admission (adjusted odds ratio [AOR] = 7.8, 95% confidence interval [CI] = 3.7-16, P < 0.001), anemia (hematocrit <30%) (AOR = 3.9, 95% CI = 2.3-6.5, P < 0.001), no coincident P. vivax malaria (AOR = 3.5, 95% CI = 1.04-11.5, P < 0.04), presentation with a recrudescent infection (AOR - 2.3, 95% CI = 1.3-4.1, P < 0.004), and a history of illness longer than two days (AOR = 3.3, 95% CI = 1.7-6.6, P < 0.001). Patients whose infections responded slowly to treatment or recrudesced subsequently were also more likely to carry gametocytes than those who responded rapidly or were cured (relative risks = 1.9, 95% CI = 1.3-2.7 and 2.8, 95% CI 2.0-4.0, respectively; P < 0.001). These data provide further evidence of important epidemiologic interactions between P. falciparum and P. vivax, and drug resistance and transmission potential.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0032985269&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/25477
ISSN: 00029637
Appears in Collections:Scopus 1991-2000

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