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dc.contributor.authorR. N. Priceen_US
dc.contributor.authorC. Cassaren_US
dc.contributor.authorA. Brockmanen_US
dc.contributor.authorM. Duraisinghen_US
dc.contributor.authorM. Van Vugten_US
dc.contributor.authorN. J. Whiteen_US
dc.contributor.authorF. Nostenen_US
dc.contributor.authorS. Krishnaen_US
dc.contributor.otherSt George's University of Londonen_US
dc.contributor.otherLondon School of Hygiene & Tropical Medicineen_US
dc.contributor.otherJohn Radcliffe Hospitalen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherAcademic Medical Centre, University of Amsterdamen_US
dc.date.accessioned2018-09-07T08:53:03Z-
dc.date.available2018-09-07T08:53:03Z-
dc.date.issued1999-12-22en_US
dc.identifier.citationAntimicrobial Agents and Chemotherapy. Vol.43, No.12 (1999), 2943-2949en_US
dc.identifier.issn00664804en_US
dc.identifier.other2-s2.0-0032804039en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0032804039&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/25490-
dc.description.abstractOn the western border of Thailand, Plasmodium falciparum has become resistant to almost all antimalarial agents. The molecular basis of resistance in these parasite populations has not been well characterized. This study assessed genetic polymorphisms in the pfmdr1 gene in 54 parasites collected from the western border of Thailand to determine the relationship of pfmdr1 copy number and codon mutations with parasite sensitivities to mefloquine, chloroquine, halofantrine, quinine, and artesunate assessed in vitro. A point mutation at codon 86 (resulting in a change of Asn to Tyr) was associated with a significantly lower 50% inhibitory concentration (IC50) of mefloquine (median, 9 ng/ml versus 52.4 ng/ml; P = 0.003). Overall 35% of the isolates (19 of 54) had an increase in pfmdr1 copy number, and all 19 carried the wild-type allele at codon 86. Increased pfmdr1 copy number was associated with higher IC50s of mefloquine (P = 0.04) and artesunate (P = 0.005), independent of polymorphism at codon 86. The relationship between pfmdr1 and resistance to structurally distinct antimalarial agents confirms the presence of a true multidrug-resistant phenotype.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0032804039&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleThe pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailanden_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
Appears in Collections:Scopus 1991-2000

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