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Title: Elevated plasma concentrations of interferon (IFN)-γ and the IFN-γ- inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis
Authors: Fanny N. Lauw
Andrew J.H. Simpson
Jan M. Prins
Michael D. Smith
Masashi Kurimoto
Sander J.H. Van Deventer
Peter Speelman
Wipada Chaowagul
Nicholas J. White
Tom Van Der Poll
Academic Medical Centre, University of Amsterdam
Mahidol University
Sappasitthiprasong Hospital
Nuffield Department of Clinical Medicine
Hayashibara Group
Keywords: Medicine
Issue Date: 17-Dec-1999
Citation: Journal of Infectious Diseases. Vol.180, No.6 (1999), 1878-1885
Abstract: Interferon (IFN)-γ plays an important role in the pathogenesis of sepsis. Production of IFN-γ is stimulated by synergistic effects of interleukin (IL)-18, IL-12, and IL-15. To investigate the regulation of IFN- γ production during severe gram-negative infection, the plasma concentrations of IFN-γ, IL-18, IL-12, and IL-15 were measured in 83 patients with suspected melioidosis. The diagnosis was confirmed in 62 patients, 31 of whom had blood cultures positive for Burkholderia pseudomallei, of whom 12 died. Compared with healthy controls, patients had elevated levels of [FN-γ, IL-18, IL-12p40, and IL-15 on admission, with significantly higher levels in blood culture-positive patients, and these levels remained elevated during the 72-h study period. In whole blood stimulated with heat-killed B. pseudomallei, anti-IL-12 had a stronger inhibitory effect than anti-IL-18 and anti-IL-15 on IFN-γ production. This effect of anti-IL-12 was further enhanced by anti-IL-18. These data suggest that during gram-negative sepsis, IFN-γ production is controlled at least in part by endogenous IL-18, IL-12, and IL-15.
ISSN: 00221899
Appears in Collections:Scopus 1991-2000

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