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Title: Reduction of rotavirus infection in children receiving bifidobacteria-supplemented formula
Authors: Pornpimon Phuapradit
Wandee Varavithya
Kanda Vathanophas
Rawiwan Sangchai
Amornrath Podhipak
Umaporn Suthutvoravut
Supachara Nopchinda
Vinitta Chantraruksa
Ferdinand Haschke
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Mahidol University
Nestle S.A.
Keywords: Medicine
Issue Date: 1-Dec-1999
Citation: Journal of the Medical Association of Thailand. Vol.82, No.SUPPL. (1999)
Abstract: This study was conducted at Pakkred Babies Home, Bangkok, Thailand; with the hypothesis that children receiving probiotic-supplemented milk-based formula may be protected from developing diarrheal diseases. Salivary rotavirus-specific IgA antibody was used as an indicator of rotavirus infection. One hundred and seventy-five children, aged 6-36 months, were enrolled in the study. They were divided into 3 groups according to the type of formula given. There were 81 episodes of diarrhea during an 8-month study period, most of which were caused by bacterial enteropathogens. Ninety-seven pairs of salivary samples were adequate for the analysis of rotavirus antibody. Among 23 children receiving milk-based follow-up formula and serving as control group, 30.4 per cent of them had ≥ 4-fold increase in the antibody titre, indicating subclinical rotavirus infection. The majority of children in the other 2 study groups, receiving the same formula supplemented with either Bifidobacterium Bbl2 alone or together with Streptococcus thermophilus, had no significant change in the antibody titres between the two time points. The results of this study support our hypothesis that children receiving bifidobacteria-supplemented milk-based formula may be protected against symptomatic rotavirus infection.
ISSN: 01252208
Appears in Collections:Scopus 1991-2000

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