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Title: The prevalence of Chlamydia pneumoniae antibodies in Thai patients with coronary artery disease
Authors: Wattana Leowattana
Kiertijai Bhuripunyo
Sasikant Pokum
Nithi Mahanonda
Amorn Leelarasamee
Bootsaba Suwimol
Mahidol University
Keywords: Medicine
Issue Date: 1-Aug-1999
Citation: Journal of the Medical Association of Thailand. Vol.82, No.8 (1999), 791-796
Abstract: Blood samples were obtained from 243 consecutive coronary artery disease (CAD) patients (177 male, 66 female) aged 35-78 years (mean, 61 years) admitted for coronary angiography because of suspected coronary heart disease, and from 115 blood donors (91 male, 24 female) aged 25-60 years (mean, 47 years). Of the 243 CAD patients, 179 (74%) were positive by an ELISA method for Chlamydia pneumoniae antibodies IgG and 132 (54%) were positive for C. pneumoniae IgA. Among the 115 blood donors, 80 (70%) were positive for C. pneumoniae IgG and 49 (43%) were positive for C. pneumoniae IgA. When IgG antibodies were considered, there was no significant difference between CAD patients and healthy controls (OR = 1.29, 95% CI = 0.79-2.10, p>0.05). In cases of positive IgA antibodies alone, there was a significant difference between CAD patients and healthy controls (OR = 1.58, 95% CI = 1.01-2.4, p = 0.029). If both IgG and IgA antibodies were positive, OR was increased from 1.58 to 1.80 (95% CI = 0.97-3.36, p = 0.044). In conclusion, C. pneumoniae infection is common in Thai people but chronic C. pneumoniae infection is more common in CAD patients than in middle-aged blood donors.
ISSN: 01252208
Appears in Collections:Scopus 1991-2000

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