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Title: Identification of circulating antibodies in fasciolosis and localization of 66 kDa antigenic target using monoclonal antibodies
Authors: D. Krailas
V. Viyanant
P. Ardseungnoen
P. Sobhon
E. S. Upatham
R. Keawjam
Mahidol University
Keywords: Medicine
Issue Date: 1-Mar-1999
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.17, No.1 (1999), 53-58
Abstract: We identified three specific circulating antibodies in serum of cattle naturally infected with Fasciola gigantica. Two of the antibodies were found to react specifically to 97 and 66 kDa antigenic molecules of adult worm tegumental membrane extract. The third antibody was identified by the reaction with 26-28 kDa molecule of the excretory/secretory antigens. Monoclonal antibody against 66 kDa protein was developed and used for localization of its antigenic target in adult worm frozen sections. The experiment demonstrated that 66 kDa protein is a component on the outer surface membrane and on the membrane lining of the caecal epithelial of adult worm. The 66 kDa antigen was considered as a promising candidate for immunodiagnosis and vaccine.
ISSN: 0125877X
Appears in Collections:Scopus 1991-2000

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