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dc.contributor.authorRic Priceen_US
dc.contributor.authorJulie A. Simpsonen_US
dc.contributor.authorPaktiya Teja-Isavatharmen_US
dc.contributor.authorMyint Myint Thanen_US
dc.contributor.authorChristine Luxemburgeren_US
dc.contributor.authorD. Gray Heppneren_US
dc.contributor.authorTan Chongsuphajaisiddhien_US
dc.contributor.authorFrançois Nostenen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherSt George's University of Londonen_US
dc.contributor.otherJohn Radcliffe Hospitalen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciences, Thailanden_US
dc.contributor.otherWalter Reed Army Institute of Researchen_US
dc.identifier.citationAntimicrobial Agents and Chemotherapy. Vol.43, No.2 (1999), 341-346en_US
dc.description.abstractCombining artemisinin or a derivative with mefloquine increases cure rates in falciparum malaria patients, reduces transmission, and may slow the development of resistance. The combination of artesunate, given for 3 days, and mefloquine is now the treatment of choice for uncomplicated multidrug- resistant falciparum malaria acquired on the western or eastern borders of Thailand. To optimize mefloquine administration in this combination, a prospective study of mefloquine pharmacokinetics was conducted with 120 children (4 to 15 years old) with acute uncomplicated falciparum malaria, who were divided into four age- and sex-matched groups. The patients all received artesunate (4 mg/kg of body weight/day orally for 3 days and mefloquine as either (i) a single dose (25 mg/kg) on day 2 with food, (ii) a split dose (15 mg/kg on day 2 and 10 mg/kg on day 3) with food, (iii) a single dose (25 mg/kg) on day 0 without food, or (iv) a single dose (25 mg/kg) on day 2 without food. Delaying administration of mefloquine until day 2 was associated with a mean (95% confidence interval) increase in estimated oral bioavailability of 72% (36 to 109%). On day 2 coadministration with food did not increase mefloquine absorption significantly, and there were no significant differences between patients receiving split- and single-dose administration. In combination with artesunate, mefloquine administration should be delayed until the second or third day after presentation.en_US
dc.rightsMahidol Universityen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titlePharmacokinetics of mefloquine combined with artesunate in children with acute falciparum malariaen_US
Appears in Collections:Scopus 1991-2000

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