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Title: Reference value for urinary deoxypyridinoline as a specific marker for measuring bone resorption in Thais
Authors: Phannee Pidetcha
Kingkaew Patrakarn
Somsak Fongsupa
Srisanit Intramanee
Pairoj Leelahakul
Mahidol University
Thammasat University
Keywords: Medicine
Issue Date: 1-Jan-1999
Citation: Journal of the Medical Association of Thailand. Vol.82, No.11 (1999), 1135-1140
Abstract: In the next century, the increasing number of elderly and rising healthcare costs will bring with it metabolic bone problems, particularly osteoporosis. Deoxypyridinoline: Dpd in urine is a sensitive and specific marker for screening and monitoring of bone resorption in a variety of diseases affecting bone turnover and in risk groups especially in the postmenopause. The reference value among aging (21-60 years) of a healthy well defined group was studied by collecting the urine between 700-1000 hours and using the ELISA technique to determine the level of Dpd. The reference value of Dpd in 113 males and 298 females 1.3-6.5 and 1.5-6.9 nm Dpd/nm Creatinine respectively. The level of Dpd in females was significantly higher than in males at p<0.028. However, the average value of deoxypyridinoline in postmenopause was higher than premenopause but not different at p = 0.05. There are many factors which influence the results so the overall reference value is only a guideline for screening in bone resorption.
ISSN: 01252208
Appears in Collections:Scopus 1991-2000

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