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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/25900
Title: A new polymorphism in the promoter region of the human interleukin-16 (IL-16) gene
Authors: E. E. Nakayama
C. Wasi
A. Ajisawa
A. Iwamoto
T. Shioda
Institute of Medical Science The University of Tokyo
Mahidol University
Tokyo Metropolitan Komagome Hospital
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2000
Citation: Genes and Immunity. Vol.1, No.4 (2000), 293-294
Abstract: Interleukin 16 (IL-16) is a chemotactic cytokine which binds to CD4 and affects T cell activation. Here we report a novel single nucleotide polymorphism, T to C, in the promoter region of the IL-16 gene in two distinct Asian populations, Japanese and Thai. This mutation occurs at an allele frequency of approximately 22% and 18%-respectively. Although IL-16 potently suppresses replication of human immunodeficiency virus type 1 (HIV-1), we observed no significant difference in the allele frequency of this polymorphism between HIV-1-infected and non-HIV-1-infected individuals in both Asian populations. Since differential IL-16 levels have been reported to be associated with inflammatory diseases such as systemic lupus erythematosus, atopic dermatitis and allergic asthma, it would be of interest to analyze the allele frequency of this mutation in patients with these autoimmune and allergic diseases.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034577203&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/25900
ISSN: 14664879
Appears in Collections:Scopus 1991-2000

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