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dc.contributor.authorE. E. Nakayamaen_US
dc.contributor.authorC. Wasien_US
dc.contributor.authorA. Ajisawaen_US
dc.contributor.authorA. Iwamotoen_US
dc.contributor.authorT. Shiodaen_US
dc.contributor.otherInstitute of Medical Science The University of Tokyoen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherTokyo Metropolitan Komagome Hospitalen_US
dc.identifier.citationGenes and Immunity. Vol.1, No.4 (2000), 293-294en_US
dc.description.abstractInterleukin 16 (IL-16) is a chemotactic cytokine which binds to CD4 and affects T cell activation. Here we report a novel single nucleotide polymorphism, T to C, in the promoter region of the IL-16 gene in two distinct Asian populations, Japanese and Thai. This mutation occurs at an allele frequency of approximately 22% and 18%-respectively. Although IL-16 potently suppresses replication of human immunodeficiency virus type 1 (HIV-1), we observed no significant difference in the allele frequency of this polymorphism between HIV-1-infected and non-HIV-1-infected individuals in both Asian populations. Since differential IL-16 levels have been reported to be associated with inflammatory diseases such as systemic lupus erythematosus, atopic dermatitis and allergic asthma, it would be of interest to analyze the allele frequency of this mutation in patients with these autoimmune and allergic diseases.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleA new polymorphism in the promoter region of the human interleukin-16 (IL-16) geneen_US
Appears in Collections:Scopus 1991-2000

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