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dc.contributor.authorHenry A.F. Stephensen_US
dc.contributor.authorDasnayanee Chandanayingyongen_US
dc.contributor.authorWarunee Kunachiwaen_US
dc.contributor.authorMonchan Sirikongen_US
dc.contributor.authorKomon Longtaen_US
dc.contributor.authorRatchaneewan Maneemarojen_US
dc.contributor.authorDonduredee Wongkuttiyaen_US
dc.contributor.authorNopporn Sittisombuten_US
dc.contributor.authorEkaraj Rungruangen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUCL Medical School Institute of Urology and Nephrologyen_US
dc.contributor.otherChiang Mai Universityen_US
dc.contributor.otherPhramongkutklao College of Medicineen_US
dc.contributor.otherUCL Medical Schoolen_US
dc.identifier.citationHuman Immunology. Vol.61, No.10 (2000), 1039-1047en_US
dc.description.abstractUsing PCR-SSOP typing we have deduced the composition and frequency of HLA-DRB1, -DRB3, -DRB4, -DRB5, -DQA1, and -DQB1 alleles present in DR51-, DR52-, and DR53-related haplotypes, in 519 individuals representative of five ethnic Thai populations recruited in central, northeastern and northern Thailand. In total, we have unequivocally detected at varying frequencies, 17 DR51-related haplotypes, 24 DR52 haplotypes, and 12 DR53 haplotypes in the study groups. We document evidence of north-south gradients of DR51-related haplotypes, whereby the overall frequency of DR51-containing haplotypes is relatively more common in the northern Thai groups. Similarly, within DR53-related haplotypes the frequency of DRB1*0901-containing haplotypes increases in the mole northerly groups, and an inverse effect was observed with DRB1*0701 containing haplotypes that were relatively more common in the northeastern and central Thais. We have also compared the class II haplotype profiles of the Thais with the equivalent profiles reported in other non-Thai ethnic groups from mainland and insular SE Asia. One DR51-related haplotype DRB1*1502x, DRB5*0102x, DQA1*0101/4, DQB1*0501, would appear to be characteristic of Thai populations, as it was the most common DR2 haplotype in all five study groups and is also prevalent in other mainland southeast Asians, but is much less evident in the more northern populations of eastern Asia or China. (C) American Society for Histocompatibility and Immunogenetics, 2000.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleA comparison of molecular HLA-DR and DQ allele profiles forming DR51-, DR52-, and DR53-related haplotypes in five ethnic Thai populations from mainland southeast Asiaen_US
Appears in Collections:Scopus 1991-2000

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