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Title: Clinical trial of sequential treatments of moderately severe and severe malaria with dihydroartemisinin suppository followed by mefloquine in Thailand
Authors: P. Wilairatna
S. Krudsood
U. Silachamroon
P. Singhasivanon
S. Vannaphan
S. Faithong
M. Klabprasit
S. Na Bangchang
P. Olliaro
S. Looareesuwan
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Dec-2000
Citation: American Journal of Tropical Medicine and Hygiene. Vol.63, No.5-6 (2000), 290-294
Abstract: One hundred and fifty patients with severe falciparum malaria were administered sequential combination of dihydroartemisinin suppository followed by an oral mefloquine tablet. Dihydroartemisinin suppositories (80 mg/ capsule) were given rectally once daily for 3 days with a total dose of 8-10 mg/kg. Two doses of mefloquine, 15 mg/kg/dose and 10 mg/kg/dose, were given at 72 hr and 84 hr, respectively. The mean [SD] parasite clearance time and fever clearance time were 46.1 [15.7] hr and 82.5 [59.6] hr, respectively. No death or major adverse drug effects occurred. The cure rate at 28 days of inpatient follow-up was 95% (113 of 119 patients). In severe malaria, dihydroartemisinin suppository followed by oral mefloquine is a suitable alternative treatment to parenteral drugs.
ISSN: 00029637
Appears in Collections:Scopus 1991-2000

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